The surname Sprouse was first found in Holland, where the name became noted for its many branches in the region, each house acquiring a status and influence which was envied by the princes of the region. The name was first recorded in South Holland, a province of Holland, the most crowded province of the Netherlands. The principal cities are Rotterdam, Leyden and Shiedam. Noted is the famed castle of Teilengen where Jacqueline of Bavaria is buried. In their later history the surname became a power unto themselves and were elevated to the ranks of nobility as they grew into this most influential family. They held a family seat in Shiedam and one of the founder families of the region.
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Vic Sprouse (b. 1968), American Republican politician, Member of West Virginia State House of Delegates; Elected 1994; Member of West Virginia State Senate 8th District, 1997-; Delegate to Republican National Convention from West Virginia, 2000, 2004 
Scott Sprouse, American Democratic Party politician, Alternate Delegate to Democratic National Convention from Tennessee, 1996 
Ronald Sprouse, American Republican politician, Alternate Delegate to Republican National Convention from Missouri, 2008 
Philip Dodson Sprouse (1906-1977), American politician, U.S. Ambassador to Cambodia, 1962 
James M. Sprouse (b. 1923), American Democratic Party politician,West Virginia Democratic State Chair, 1965-68; Candidate for Governor of West Virginia, 1968; Judge of West Virginia supreme court of appeals, 1973-75; Judge of U.S. Court of Appeals for the 4th Circuit, 1979-92 
Dorothy Sprouse, American Republican politician, Delegate to Republican National Convention from Missouri, 2008 
Barry W. Sprouse, American Democratic Party politician, Delegate to Democratic National Convention from Texas, 1996 
Bill Sprouse Jr. (d. 1975), American Christian evangelist, singer and songwriter
Stephen Sprouse (1953-2004), American fashion designer and artist
Dylan Thomas and Cole Mitchell Sprouse (b. 1992), American twin actors, best known for their roles on the Disney Channel sitcom The Suite Life of Zack & Cody and later The Suite Life on Deck, recipients of numerours Kids' Choice Awards