The distinguished surname Luisi has its origins in Spain. However, it appears to have been derived from the Germanic Lodowicus, which is composed of the elements "hlod," meaning "fame" and "wig," meaning "war."
The surname Luisi was first found in Aragon, in the northeastern region of the Iberian peninsula. Luisi was the surname of a very noble family, proceeding from Aragon, but originating from France. One of the earliest references to this name is a record of Bartolome Luis, who entered the Infantry of the Royal Army in the year 1867.
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Some of the first settlers of this family name or some of its variants were: Ines Luis who immigrated to the Spanish Main in 1561; Catalina Luis who came to New Spain in 1569; and Ines Luis who arrived in Peru in 1592 with his family. Among later settlers were Juan Bautista Luis who immigrated to Puerto Rico in 1816.