The noble surname Cartagena is of Spanish descent, and appears to be of toponymic origin, derived from the place name where the original bearer first lived or owned land. Thus, the name Cartagena signifies "one who hails from the city of Cartagena."
The surname Cartagena was first found in the Castilian province of Burgos. Early records of the surname Cartagena mention Alonso de Santa María de Cartagena who was born in Burgos in 1384 and was a distinguished politician, poet and philosopher of his time.
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