First found in Connacht, where the Blake family were one of the Tribes of Galway, descending from Richard Caddell (le Blac), sheriff of Connacht in 1303, who came to Ireland with Prince John in 1185, and used both the surnames Caddell and Blake. The name Caddell is Welsh, and means "warlike." It was not replaced completely by Blake until the 17th century, and for three hundred years, people with these surnames were referred to in municipal records by both names. Richard Caddle was sheriff of Connaught in 1306 A.D. and was a tenant of Falway under Richard de Burgo (Burke), the Red Earl of Ulster.

Many destitute Irish Families in the 18th and 19th centuries decided to leave their homeland, which had in many ways been scarred by English colonial rule. One of the most frequent destinations for these families was North America where it was possible for an Irish family to own their own parcel of land. Many of the early settlers did find land awaiting them in British North America, or even later in America, but for the majority of immigrants that arrived as a result of the Great Potato Famine of the late 1840s the ownership of land was often a long way off. These Irish people were initially put to work on such industrial projects as the building of bridges, canals, and railroads, or they worked at manufacturing positions within factories. Whenever they arrived, the Irish made enormous contributions to the infant nations of Canada and the United States. Some of the earliest immigrants to bearer the name of Caddle were found through extensive research of immigration and passenger lists: William Blake who came from Essex, England, sailed on the "Mary and John" in 1630 and settled in Dorchester, Massachusetts; George Blake settled in Gloucester in 1640.

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