Jennifer Lynn Lopez (b. 1969), American actress, singer, record producer, dancer, television personality, fashion designer and television producer
Donald S. Lopez Sr. (1923-2008), former U.S. Army and U.S. Air Force fighter and test pilot and, until his death, the deputy director of the Smithsonian National Air and Space Museum
Steven López (b. 1978), American 2000 and 2004 Olympic gold medalist in taekwondo
Marco Antonio Lopez (b. 1978), American politician and United States Chief of Staff for Customs and Border Protection (2009-)
Barry Holstun Lopez (b. 1945), American author, essayist, and fiction writer
